Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

Optimization of our previously described peptidomimetic furin inhibitors was performed and yielded several analogs with a significantly improved activity. The most potent compounds containing an N-terminal 4- or 3-(guanidinomethyl)phenylacetyl residue inhibit furin with K(i) values of 16 and 8 pm, r...

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Detalhes bibliográficos
Main Authors: Becker, Gero L., Lu, Yinghui, Hardes, Kornelia, Strehlow, Boris, Levesque, Christine, Lindberg, Iris, Sandvig, Kirsten, Bakowsky, Udo, Day, Robert, Garten, Wolfgang, Steinmetzer, Torsten
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381159/
https://ncbi.nlm.nih.gov/pubmed/22539349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.332643
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