Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

Optimization of our previously described peptidomimetic furin inhibitors was performed and yielded several analogs with a significantly improved activity. The most potent compounds containing an N-terminal 4- or 3-(guanidinomethyl)phenylacetyl residue inhibit furin with K(i) values of 16 and 8 pm, r...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Becker, Gero L., Lu, Yinghui, Hardes, Kornelia, Strehlow, Boris, Levesque, Christine, Lindberg, Iris, Sandvig, Kirsten, Bakowsky, Udo, Day, Robert, Garten, Wolfgang, Steinmetzer, Torsten
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Enzymology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381159/
https://ncbi.nlm.nih.gov/pubmed/22539349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.332643
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia