Elongated and shortened peptidomimetic inhibitors of the proprotein convertase furin

Novel elongated and shortened derivatives of the peptidomimetic furin inhibitor phenylacteyl-Arg-Val-Arg-4-amidinobenzylamide were synthesized. The most potent compounds, e.g., N(α)(carbamidoyl)Arg-Arg-Val-Arg-4-amidinobenzylamide (K(i) = 6.2 pM), contain additional basic residues at the N-terminus...

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Publicado en:ChemMedChem
Main Authors: Hardes, Kornelia, Ivanova, Teodora, Thaa, Bastian, McInerney, Gerald M., Klokk, Tove Irene, Sandvig, Kirsten, Künzel, Sebastian, Lindberg, Iris, Steinmetzer, Torsten
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572662/
https://ncbi.nlm.nih.gov/pubmed/28334511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700108
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