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Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism
Proprotein convertases (PCs) are highly specific proteases required for the proteolytic modification of many secreted proteins. An unbalanced activity of these enzymes is connected to pathologies like cancer, atherosclerosis, hypercholesterolaemia, and infectious diseases. Novel protein crystallogra...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5056075/ https://ncbi.nlm.nih.gov/pubmed/27647913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613630113 |
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