Loading...
The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers
Proprotein Convertases (PCs) represent highly selective serine proteases that activate their substrates upon proteolytic cleavage. Their inhibition is a promising strategy for the treatment of cancer and infectious diseases. Inhibitory camelid antibodies were developed, targeting the prototypical PC...
Na minha lista:
| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5037460/ https://ncbi.nlm.nih.gov/pubmed/27670069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34303 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|