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Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile
Localized mainly to endo/lysosomes, legumain plays an important role in exogenous antigen processing and presentation. The cysteine protease legumain, also known as asparaginyl endopepetidase AEP, is synthesized as a zymogen and is known to undergo pH-dependent autoproteolytic activation whereby N-t...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
International Union of Crystallography
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3253828/ https://ncbi.nlm.nih.gov/pubmed/22232165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111048020 |
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