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Structure and Mechanism of an Aspartimide-Dependent Peptide Ligase in Human Legumain**
Peptide ligases expand the repertoire of genetically encoded protein architectures by synthesizing new peptide bonds, energetically driven by ATP or NTPs. Here, we report the discovery of a genuine ligase activity in human legumain (AEP) which has important roles in immunity and tumor progression th...
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| Vydáno v: | Angew Chem Int Ed Engl |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
WILEY-VCH Verlag
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506564/ https://ncbi.nlm.nih.gov/pubmed/25630877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201409135 |
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