Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone

The Nestin-Cre driver mouse line has mild hypopituitarism, reduced body weight, a metabolic phenotype and reduced anxiety. Although several causes have been suggested, a comprehensive explanation is still lacking. In this study we examined the molecular mechanisms leading to this compound phenotype....

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Declercq, Jeroen, Brouwers, Bas, Pruniau, Vincent P. E. G., Stijnen, Pieter, de Faudeur, Geoffroy, Tuand, Krizia, Meulemans, Sandra, Serneels, Lutgarde, Schraenen, Anica, Schuit, Frans, Creemers, John W. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537087/
https://ncbi.nlm.nih.gov/pubmed/26275221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135502
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