The composition of the γ-secretase complex defines its Aβ product profile

Autor Acx, Hermien, Gutiérrez, Lucía Chávez, Serneels, Lutgarde, De Strooper, Bart
Vydáno 2013

α2-Macroglobulin- and Murinoglobulin-1- Deficient Mice : A Mouse Model for Acute Pancreatitis

Autor Umans, Lieve, Serneels, Lutgarde, Overbergh, Lut, Stas, Lou, Van Leuven, Fred
Vydáno 1999

Peroxisome Proliferator-Activated Receptor γ Induces a Clearance Mechanism for the Amyloid-β Peptide

Autor Camacho, Ira Espuny, Serneels, Lutgarde, Spittaels, Kurt, Merchiers, Pascal, Dominguez, Diana, De Strooper, Bart
Vydáno v J Neurosci (2004)

Rer1p competes with APH-1 for binding to nicastrin and regulates γ-secretase complex assembly in the early secretory pathway

Autor Spasic, Dragana, Raemaekers, Tim, Dillen, Katleen, Declerck, Ilse, Baert, Veerle, Serneels, Lutgarde, Füllekrug, Joachim, Annaert, Wim
Vydáno 2007

Signature Amyloid β Profiles Are Produced by Different γ-Secretase Complexes

Autor Acx, Hermien, Chávez-Gutiérrez, Lucía, Serneels, Lutgarde, Lismont, Sam, Benurwar, Manasi, Elad, Nadav, De Strooper, Bart
Vydáno 2014

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Autor Serneels, Lutgarde, T’Syen, Dries, Perez-Benito, Laura, Theys, Tom, Holt, Matthew G., De Strooper, Bart
Vydáno v Mol Neurodegener (2020)

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

Autor Hébert, Sébastien S, Serneels, Lutgarde, Tolia, Alexandra, Craessaerts, Katleen, Derks, Carmen, Filippov, Mikhail A, Müller, Ulrike, De Strooper, Bart
Vydáno 2006

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

Autor Fazzari, Pietro, Snellinx, An, Sabanov, Victor, Ahmed, Tariq, Serneels, Lutgarde, Gartner, Annette, Shariati, S Ali M, Balschun, Detlef, De Strooper, Bart
Vydáno 2014

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

Autor Acx, Hermien, Serneels, Lutgarde, Radaelli, Enrico, Muyldermans, Serge, Vincke, Cécile, Pepermans, Elise, Müller, Ulrike, Chávez‐Gutiérrez, Lucía, De Strooper, Bart
Vydáno v EMBO Mol Med (2017)

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease

Autor Brownjohn, Philip W., Smith, James, Portelius, Erik, Serneels, Lutgarde, Kvartsberg, Hlin, De Strooper, Bart, Blennow, Kaj, Zetterberg, Henrik, Livesey, Frederick J.
Vydáno v Stem Cell Reports (2017)

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

Autor Rochin, Leila, Hurbain, Ilse, Serneels, Lutgarde, Fort, Cecile, Watt, Brenda, Leblanc, Pascal, Marks, Michael S., De Strooper, Bart, Raposo, Graça, van Niel, Guillaume
Vydáno 2013

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

Autor Esselens, Cary, Oorschot, Viola, Baert, Veerle, Raemaekers, Tim, Spittaels, Kurt, Serneels, Lutgarde, Zheng, Hui, Saftig, Paul, De Strooper, Bart, Klumperman, Judith, Annaert, Wim
Vydáno 2004

Presenilins Form ER Ca(2+) Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Autor Tu, Huiping, Nelson, Omar, Bezprozvanny, Arseny, Wang, Zhengnan, Lee, Sheu-Fen, Hao, Yi-Heng, Serneels, Lutgarde, De Strooper, Bart, Yu, Gang, Bezprozvanny, Ilya
Vydáno 2006

Differential contribution of the three Aph1 genes to γ-secretase activity in vivo

Autor Serneels, Lutgarde, Dejaegere, Tim, Craessaerts, Katleen, Horré, Katrien, Jorissen, Ellen, Tousseyn, Thomas, Hébert, Sébastien, Coolen, Marcel, Martens, Gerard, Zwijsen, An, Annaert, Wim, Hartmann, Dieter, De Strooper, Bart
Vydáno 2005

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

Autor Tousseyn, Thomas, Thathiah, Amantha, Jorissen, Ellen, Raemaekers, Tim, Konietzko, Uwe, Reiss, Karina, Maes, Elke, Snellinx, An, Serneels, Lutgarde, Nyabi, Omar, Annaert, Wim, Saftig, Paul, Hartmann, Dieter, De Strooper, Bart
Vydáno 2009

Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone

Autor Declercq, Jeroen, Brouwers, Bas, Pruniau, Vincent P. E. G., Stijnen, Pieter, de Faudeur, Geoffroy, Tuand, Krizia, Meulemans, Sandra, Serneels, Lutgarde, Schraenen, Anica, Schuit, Frans, Creemers, John W. M.
Vydáno v PLoS One (2015)

Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I...

Autor Dewachter, Ilse, Reversé, Delphine, Caluwaerts, Nathalie, Ris, Laurence, Kuipéri, Cuno, Van den Haute, Chris, Spittaels, Kurt, Umans, Lieve, Serneels, Lutgarde, Thiry, Els, Moechars, Dieder, Mercken, Mark, Godaux, Emile, Van Leuven, Fred
Vydáno v J Neurosci (2002)

PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome

Autor Spinazzi, Marco, Radaelli, Enrico, Horré, Katrien, Arranz, Amaia M., Gounko, Natalia V., Agostinis, Patrizia, Maia, Teresa Mendes, Impens, Francis, Morais, Vanessa Alexandra, Lopez-Lluch, Guillermo, Serneels, Lutgarde, Navas, Placido, De Strooper, Bart
Vydáno v Proc Natl Acad Sci U S A (2019)

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

Autor Jorissen, Ellen, Prox, Johannes, Bernreuther, Christian, Weber, Silvio, Schwanbeck, Ralf, Serneels, Lutgarde, Snellinx, An, Craessaerts, Katleen, Thathiah, Amantha, Tesseur, Ina, Bartsch, Udo, Weskamp, Gisela, Blobel, Carl P., Glatzel, Markus, De Strooper, Bart, Saftig, Paul
Vydáno 2010

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficie...

Autor Herreman, An, Hartmann, Dieter, Annaert, Wim, Saftig, Paul, Craessaerts, Katleen, Serneels, Lutgarde, Umans, Lieve, Schrijvers, Vincent, Checler, Frédéric, Vanderstichele, Hugo, Baekelandt, Veerle, Dressel, Ralf, Cupers, Philippe, Huylebroeck, Danny, Zwijsen, An, Van Leuven, Fred, De Strooper, Bart
Vydáno 1999