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Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

γ-Secretase-dependent regulated intramembrane proteolysis of amyloid precursor protein (APP) releases the APP intracellular domain (AICD). The question of whether this domain, like the Notch intracellular domain, is involved in nuclear signalling is highly controversial. Although some reports sugges...

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Bibliografiske detaljer
Main Authors: Hébert, Sébastien S, Serneels, Lutgarde, Tolia, Alexandra, Craessaerts, Katleen, Derks, Carmen, Filippov, Mikhail A, Müller, Ulrike, De Strooper, Bart
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500829/
https://ncbi.nlm.nih.gov/pubmed/16729020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400704
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