Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

γ-Secretase-dependent regulated intramembrane proteolysis of amyloid precursor protein (APP) releases the APP intracellular domain (AICD). The question of whether this domain, like the Notch intracellular domain, is involved in nuclear signalling is highly controversial. Although some reports sugges...

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Autores principales: Hébert, Sébastien S, Serneels, Lutgarde, Tolia, Alexandra, Craessaerts, Katleen, Derks, Carmen, Filippov, Mikhail A, Müller, Ulrike, De Strooper, Bart
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2006
Materias:
Scientific Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500829/
https://ncbi.nlm.nih.gov/pubmed/16729020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400704
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