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Intramembrane Proteolysis of β-Amyloid Precursor Protein by γ-Secretase Is an Unusually Slow Process
Intramembrane proteolysis has emerged as a key mechanism required for membrane proteostasis and cellular signaling. One of the intramembrane-cleaving proteases (I-CLiPs), γ-secretase, is also intimately implicated in Alzheimer’s disease, a major neurodegenerative disease and leading cause of dementi...
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| Publicat a: | Biophys J |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Biophysical Society
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375682/ https://ncbi.nlm.nih.gov/pubmed/25762334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.12.045 |
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