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β-Amyloid Precursor Protein Mutants Respond to γ-Secretase Modulators
Pathogenic generation of the 42-amino acid variant of the amyloid β-peptide (Aβ) by β- and γ-secretase cleavage of the β-amyloid precursor protein (APP) is believed to be causative for Alzheimer disease (AD). Lowering of Aβ(42) production by γ-secretase modulators (GSMs) is a hopeful approach toward...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2878544/ https://ncbi.nlm.nih.gov/pubmed/20348104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103283 |
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