β-Amyloid Precursor Protein Mutants Respond to γ-Secretase Modulators

Pathogenic generation of the 42-amino acid variant of the amyloid β-peptide (Aβ) by β- and γ-secretase cleavage of the β-amyloid precursor protein (APP) is believed to be causative for Alzheimer disease (AD). Lowering of Aβ(42) production by γ-secretase modulators (GSMs) is a hopeful approach toward...

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Bibliographische Detailangaben
Hauptverfasser: Page, Richard M., Gutsmiedl, Amelie, Fukumori, Akio, Winkler, Edith, Haass, Christian, Steiner, Harald
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878544/
https://ncbi.nlm.nih.gov/pubmed/20348104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103283
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