Attenuated Aβ(42) Responses to Low Potency γ-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds

Sequential processing of the β-amyloid precursor protein by β- and γ-secretase generates the amyloid β-peptide (Aβ), which is widely believed to play a causative role in Alzheimer disease. Selective lowering of the pathogenic 42-amino acid variant of Aβ by γ-secretase modulators (GSMs) is a promisin...

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Detalhes bibliográficos
Main Authors: Kretner, Benedikt, Fukumori, Akio, Gutsmiedl, Amelie, Page, Richard M., Luebbers, Thomas, Galley, Guido, Baumann, Karlheinz, Haass, Christian, Steiner, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083200/
https://ncbi.nlm.nih.gov/pubmed/21357415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.213587
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