Chargement en cours...
Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of γ-Secretase-Mediated Intramembrane Proteolysis
Presenilin (PS1 or PS2) is the catalytic component of the γ-secretase complex, which mediates the final proteolytic processing step leading to the Alzheimer's disease (AD)-characterizing amyloid β-peptide. PS is cleaved during complex assembly into its characteristic N- and C-terminal fragments...
Enregistré dans:
| Publié dans: | J Neurosci |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Neuroscience
2010
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6632680/ https://ncbi.nlm.nih.gov/pubmed/20534834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1443-10.2010 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|