Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of γ-Secretase-Mediated Intramembrane Proteolysis

Presenilin (PS1 or PS2) is the catalytic component of the γ-secretase complex, which mediates the final proteolytic processing step leading to the Alzheimer's disease (AD)-characterizing amyloid β-peptide. PS is cleaved during complex assembly into its characteristic N- and C-terminal fragments...

Full description

Saved in:
Bibliographic Details
Published in:J Neurosci
Main Authors: Fukumori, Akio, Fluhrer, Regina, Steiner, Harald, Haass, Christian
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632680/
https://ncbi.nlm.nih.gov/pubmed/20534834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1443-10.2010
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items