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Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of γ-Secretase-Mediated Intramembrane Proteolysis
Presenilin (PS1 or PS2) is the catalytic component of the γ-secretase complex, which mediates the final proteolytic processing step leading to the Alzheimer's disease (AD)-characterizing amyloid β-peptide. PS is cleaved during complex assembly into its characteristic N- and C-terminal fragments...
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| Publicat a: | J Neurosci |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Society for Neuroscience
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6632680/ https://ncbi.nlm.nih.gov/pubmed/20534834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1443-10.2010 |
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