Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein

γ-Secretase is essential for the generation of the neurotoxic 42-amino acid amyloid β-peptide (Aβ(42)). The aggregation-prone hydrophobic peptide, which is deposited in Alzheimer disease (AD) patient brain, is generated from a C-terminal fragment of the β-amyloid precursor protein by an intramembran...

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Detaylı Bibliyografya
Asıl Yazarlar: Ebke, Amelie, Luebbers, Thomas, Fukumori, Akio, Shirotani, Keiro, Haass, Christian, Baumann, Karlheinz, Steiner, Harald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Enzymology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199465/
https://ncbi.nlm.nih.gov/pubmed/21896486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.276972
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