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Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein
γ-Secretase is essential for the generation of the neurotoxic 42-amino acid amyloid β-peptide (Aβ(42)). The aggregation-prone hydrophobic peptide, which is deposited in Alzheimer disease (AD) patient brain, is generated from a C-terminal fragment of the β-amyloid precursor protein by an intramembran...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199465/ https://ncbi.nlm.nih.gov/pubmed/21896486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.276972 |
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