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Generation of Alzheimer Disease-associated Amyloid β(42/43) Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness
Pathogenic generation of amyloid β-peptide (Aβ) by sequential cleavage of β-amyloid precursor protein (APP) by β- and γ-secretases is widely believed to causally underlie Alzheimer disease (AD). β-Secretase initially cleaves APP thereby generating a membrane-bound APP C-terminal fragment, from which...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society for Biochemistry and Molecular Biology
2012
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375553/ https://ncbi.nlm.nih.gov/pubmed/22532566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.356659 |
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