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Generation of Alzheimer Disease-associated Amyloid β(42/43) Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

Pathogenic generation of amyloid β-peptide (Aβ) by sequential cleavage of β-amyloid precursor protein (APP) by β- and γ-secretases is widely believed to causally underlie Alzheimer disease (AD). β-Secretase initially cleaves APP thereby generating a membrane-bound APP C-terminal fragment, from which...

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Main Authors: Winkler, Edith, Kamp, Frits, Scheuring, Johannes, Ebke, Amelie, Fukumori, Akio, Steiner, Harald
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375553/
https://ncbi.nlm.nih.gov/pubmed/22532566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.356659
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