Cargando...
Generation of Alzheimer Disease-associated Amyloid β(42/43) Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness
Pathogenic generation of amyloid β-peptide (Aβ) by sequential cleavage of β-amyloid precursor protein (APP) by β- and γ-secretases is widely believed to causally underlie Alzheimer disease (AD). β-Secretase initially cleaves APP thereby generating a membrane-bound APP C-terminal fragment, from which...
Gardado en:
| Main Authors: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375553/ https://ncbi.nlm.nih.gov/pubmed/22532566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.356659 |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|