Intramembrane Proteolysis of GXGD-type Aspartyl Proteases Is Slowed by a Familial Alzheimer Disease-like Mutation

More than 150 familial Alzheimer disease (FAD)-associated missense mutations in presenilins (PS1 and PS2), the catalytic subunit of the γ-secretase complex, cause aberrant amyloid β-peptide (Aβ) production, by increasing the relative production of the highly amyloidogenic 42-amino acid variant. The...

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Main Authors: Fluhrer, Regina, Fukumori, Akio, Martin, Lucas, Grammer, Gudula, Haug-Kröper, Martina, Klier, Bärbel, Winkler, Edith, Kremmer, Elisabeth, Condron, Margaret M., Teplow, David B., Steiner, Harald, Haass, Christian
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2008
Ábhair:
Enzyme Catalysis and Regulation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573083/
https://ncbi.nlm.nih.gov/pubmed/18768471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806092200
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