Intramembrane Proteolysis of GXGD-type Aspartyl Proteases Is Slowed by a Familial Alzheimer Disease-like Mutation

More than 150 familial Alzheimer disease (FAD)-associated missense mutations in presenilins (PS1 and PS2), the catalytic subunit of the γ-secretase complex, cause aberrant amyloid β-peptide (Aβ) production, by increasing the relative production of the highly amyloidogenic 42-amino acid variant. The...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Fluhrer, Regina, Fukumori, Akio, Martin, Lucas, Grammer, Gudula, Haug-Kröper, Martina, Klier, Bärbel, Winkler, Edith, Kremmer, Elisabeth, Condron, Margaret M., Teplow, David B., Steiner, Harald, Haass, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Enzyme Catalysis and Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573083/
https://ncbi.nlm.nih.gov/pubmed/18768471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806092200
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi