Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis

Fe65 is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-β precursor protein, APP. Here, the subcellular localization was further investigated using TAP-tagged Fe65 constructs expressed in human neuroblastoma cells. Our results indicate that PTB2 rathe...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Koistinen, Niina A., Edlund, Anna K., Menon, Preeti K., Ivanova, Elena V., Bacanu, Smaranda, Iverfeldt, Kerstin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360310/
https://ncbi.nlm.nih.gov/pubmed/28323844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173888
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