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Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal deposition of β-amyloid (Aβ) peptides. Aβ is a cleavage product of the amyloid precursor protein (APP), and aberrant posttranslational modifications of APP can alter APP processing and increase Aβ generation. In...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6879340/ https://ncbi.nlm.nih.gov/pubmed/31604820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008310 |
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