Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal deposition of β-amyloid (Aβ) peptides. Aβ is a cleavage product of the amyloid precursor protein (APP), and aberrant posttranslational modifications of APP can alter APP processing and increase Aβ generation. In...

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Vydáno v:J Biol Chem
Hlavní autoři: Menon, Preeti Kumaran, Koistinen, Niina Anneli, Iverfeldt, Kerstin, Ström, Anna-Lena
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879340/
https://ncbi.nlm.nih.gov/pubmed/31604820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008310
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