Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APP(Sw) Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis

Alzheimer's disease (AD) may be caused by the abnormal processing of the amyloid precursor protein (APP) and the accumulation of β-amyloid (Aβ). The amyloid precursor protein can be proteolytically cleaved into multiple fragments, many of which have distinct biological actions. Although a high...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Stein, Thor D., Anders, Nicholas J., DeCarli, Charles, Chan, Sic L., Mattson, Mark P., Johnson, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729623/
https://ncbi.nlm.nih.gov/pubmed/15342738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2211-04.2004
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