Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

γ-Secretase-dependent regulated intramembrane proteolysis of amyloid precursor protein (APP) releases the APP intracellular domain (AICD). The question of whether this domain, like the Notch intracellular domain, is involved in nuclear signalling is highly controversial. Although some reports sugges...

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Detalhes bibliográficos
Main Authors: Hébert, Sébastien S, Serneels, Lutgarde, Tolia, Alexandra, Craessaerts, Katleen, Derks, Carmen, Filippov, Mikhail A, Müller, Ulrike, De Strooper, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500829/
https://ncbi.nlm.nih.gov/pubmed/16729020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400704
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