Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice

In the brain of Alzheimer's disease (AD) patients, neurotoxic amyloid peptides accumulate and are deposited as senile plaques. A major therapeutic strategy aims to decrease production of amyloid peptides by inhibition of γ-secretase. Presenilins are polytopic transmembrane proteins that are ess...

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Gepubliceerd in:J Neurosci
Hoofdauteurs: Dewachter, Ilse, Reversé, Delphine, Caluwaerts, Nathalie, Ris, Laurence, Kuipéri, Cuno, Van den Haute, Chris, Spittaels, Kurt, Umans, Lieve, Serneels, Lutgarde, Thiry, Els, Moechars, Dieder, Mercken, Mark, Godaux, Emile, Van Leuven, Fred
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2002
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758348/
https://ncbi.nlm.nih.gov/pubmed/11978821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-09-03445.2002
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