Rer1p competes with APH-1 for binding to nicastrin and regulates γ-secretase complex assembly in the early secretory pathway

The γ-secretase complex, consisting of presenilin, nicastrin, presenilin enhancer-2 (PEN-2), and anterior pharynx defective-1 (APH-1) cleaves type I integral membrane proteins like amyloid precursor protein and Notch in a process of regulated intramembrane proteolysis. The regulatory mechanisms gove...

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Detalhes bibliográficos
Main Authors: Spasic, Dragana, Raemaekers, Tim, Dillen, Katleen, Declerck, Ilse, Baert, Veerle, Serneels, Lutgarde, Füllekrug, Joachim, Annaert, Wim
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064021/
https://ncbi.nlm.nih.gov/pubmed/17325205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200609180
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