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Different cofactor activities in γ-secretase assembly: evidence for a nicastrin–Aph-1 subcomplex
The γ-secretase complex is required for intramembrane cleavage of several integral membrane proteins, including the Notch receptor, where it generates an active signaling fragment. Four putative γ-secretase components have been identified—presenilin (Psn), nicastrin (Nct), Aph-1, and Pen-2. Here, we...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2003
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2199374/ https://ncbi.nlm.nih.gov/pubmed/12771124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200304014 |
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