Evidence That the “Lid” Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity

Understanding of the structure of the γ-secretase complex consisting of presenilin (PS), anterior pharynx-defective 1 (APH-1), nicastrin (NCT), and presenilin enhancer 2 (PEN-2) is of significant therapeutic interest for the design of γ-secretase modulators for Alzheimer disease. The structure of γ-...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Zhang, Xulun, Sullivan, Eric, Scimeca, Maggie, Wu, Xianzhong, Li, Yue-ming, Sisodia, Sangram S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
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Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807262/
https://ncbi.nlm.nih.gov/pubmed/26887941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C115.701649
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