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Evidence That the “Lid” Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity
Understanding of the structure of the γ-secretase complex consisting of presenilin (PS), anterior pharynx-defective 1 (APH-1), nicastrin (NCT), and presenilin enhancer 2 (PEN-2) is of significant therapeutic interest for the design of γ-secretase modulators for Alzheimer disease. The structure of γ-...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4807262/ https://ncbi.nlm.nih.gov/pubmed/26887941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C115.701649 |
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