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Activation and intrinsic γ-secretase activity of presenilin 1
A complex composed of presenilin (PS), nicastrin, PEN-2, and APH-1 is absolutely required for γ-secretase activity in vivo. Evidence has emerged to suggest a role for PS as the catalytic subunit of γ-secretase, but it has not been established that PS is catalytically active in the absence of associa...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003001/ https://ncbi.nlm.nih.gov/pubmed/21115843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013246107 |
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