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Structure of the transmembrane domain of human nicastrin-a component of γ-secretase
Nicastrin is the largest component of γ-secretase that is an intramembrane protease important in the development of Alzheimer’s disease. Nicastrin contains a large extracellular domain, a single transmembrane (TM) domain, and a short C-terminus. Its TM domain is important for the γ-secretase complex...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4726005/ https://ncbi.nlm.nih.gov/pubmed/26776682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19522 |
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