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Crystal structure of the γ-secretase component nicastrin

γ-Secretase is an intramembrane protease responsible for the generation of amyloid-β (Aβ) peptides. Aberrant accumulation of Aβ leads to the formation of amyloid plaques in the brain of patients with Alzheimer's disease. Nicastrin is the putative substrate-recruiting component of the γ-secretas...

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Bibliografische gegevens
Hoofdauteurs: Xie, Tian, Yan, Chuangye, Zhou, Rui, Zhao, Yanyu, Sun, Linfeng, Yang, Guanghui, Lu, Peilong, Ma, Dan, Shi, Yigong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169925/
https://ncbi.nlm.nih.gov/pubmed/25197054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414837111
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