Structural basis of human γ-secretase assembly

The four-component intramembrane protease γ-secretase is intricately linked to the development of Alzheimer’s disease. Despite recent structural advances, the transmembrane segments (TMs) of γ-secretase remain to be specifically assigned. Here we report a 3D structure of human γ-secretase at 4.32-Å...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sun, Linfeng, Zhao, Lingyun, Yang, Guanghui, Yan, Chuangye, Zhou, Rui, Zhou, Xiaoyuan, Xie, Tian, Zhao, Yanyu, Wu, Shenjie, Li, Xueming, Shi, Yigong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434707/
https://ncbi.nlm.nih.gov/pubmed/25918421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506242112
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