Three-dimensional structure of human γ-secretase

The γ-secretase complex, comprising presenilin 1 (PS1), Pen-2, Aph-1, and Nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage. Aberrant cleavage of the amyloid precursor protein results in aggregation of β-amyloid peptide, whic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Lu, Peilong, Bai, Xiao-chen, Ma, Dan, Xie, Tian, Yan, Chuangye, Sun, Linfeng, Yang, Guanghui, Zhao, Yanyu, Zhou, Rui, Scheres, Sjors H.W., Shi, Yigong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134323/
https://ncbi.nlm.nih.gov/pubmed/25043039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13567
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge