Three-dimensional structure of human γ-secretase

The γ-secretase complex, comprising presenilin 1 (PS1), Pen-2, Aph-1, and Nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage. Aberrant cleavage of the amyloid precursor protein results in aggregation of β-amyloid peptide, whic...

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Bibliografiske detaljer
Main Authors: Lu, Peilong, Bai, Xiao-chen, Ma, Dan, Xie, Tian, Yan, Chuangye, Sun, Linfeng, Yang, Guanghui, Zhao, Yanyu, Zhou, Rui, Scheres, Sjors H.W., Shi, Yigong
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134323/
https://ncbi.nlm.nih.gov/pubmed/25043039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13567
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