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Three-dimensional structure of human γ-secretase
The γ-secretase complex, comprising presenilin 1 (PS1), Pen-2, Aph-1, and Nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage. Aberrant cleavage of the amyloid precursor protein results in aggregation of β-amyloid peptide, whic...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134323/ https://ncbi.nlm.nih.gov/pubmed/25043039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13567 |
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