Caricamento...

Sampling the conformational space of the catalytic subunit of human γ-secretase

Human γ-secretase is an intra-membrane protease that cleaves many different substrates. Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid precursor protein lead to Alzheimer's disease. Our previous cryo-EM structure of γ-secretase revealed considerable d...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Bai, Xiao-chen, Rajendra, Eeson, Yang, Guanghui, Shi, Yigong, Scheres, Sjors HW
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2015
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718806/
https://ncbi.nlm.nih.gov/pubmed/26623517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11182
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !