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Sampling the conformational space of the catalytic subunit of human γ-secretase
Human γ-secretase is an intra-membrane protease that cleaves many different substrates. Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid precursor protein lead to Alzheimer's disease. Our previous cryo-EM structure of γ-secretase revealed considerable d...
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| Yayımlandı: | eLife |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
eLife Sciences Publications, Ltd
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718806/ https://ncbi.nlm.nih.gov/pubmed/26623517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11182 |
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