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Contribution of the γ-Secretase Subunits to the Formation of Catalytic Pore of Presenilin 1 Protein
γ-Secretase is an intramembrane-cleaving protease related to the etiology of Alzheimer disease. γ-Secretase is a membrane protein complex composed of presenilin (PS) and three indispensable subunits: nicastrin, Aph-1, and Pen-2. PS functions as a protease subunit forming a hydrophilic catalytic pore...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406669/ https://ncbi.nlm.nih.gov/pubmed/22689582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336347 |
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