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Comparison of Presenilin 1 and Presenilin 2 γ-Secretase Activities Using a Yeast Reconstitution System

γ-Secretase is composed of at least four proteins, presenilin (PS), nicastrin (NCT), Aph1, and Pen2. PS is the catalytic subunit of the γ-secretase complex, having aspartic protease activity. PS has two homologs, namely, PS1 and PS2. To compare the activity of these complexes containing different PS...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yonemura, Yoji, Futai, Eugene, Yagishita, Sosuke, Suo, Satoshi, Tomita, Taisuke, Iwatsubo, Takeshi, Ishiura, Shoichi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247977/
https://ncbi.nlm.nih.gov/pubmed/22074918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.270108
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