Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities

γ-Secretase is a multisubunit membrane protein complex containing presenilin (PS1) as a catalytic subunit. Familial Alzheimer disease (FAD) mutations within PS1 were analyzed in yeast cells artificially expressing membrane-bound substrate, amyloid precursor protein, or Notch fused to Gal4 transcript...

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Vydáno v:J Biol Chem
Hlavní autoři: Futai, Eugene, Osawa, Satoko, Cai, Tetsuo, Fujisawa, Tomoya, Ishiura, Shoichi, Tomita, Taisuke
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697183/
https://ncbi.nlm.nih.gov/pubmed/26559975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.629287
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