Nicastrin Is Dispensable for γ-Secretase Protease Activity in the Presence of Specific Presenilin Mutations

γ-Secretase is a multisubunit membrane protein complex consisting of presenilin (PS1), nicastrin (NCT), anterior pharynx-1, and presenilin enhancer 2. To analyze the activity of familial Alzheimer disease mutants and to understand the roles of the subunits, we established a yeast transcriptional act...

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Bibliographic Details
Main Authors: Futai, Eugene, Yagishita, Sosuke, Ishiura, Shoichi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676034/
https://ncbi.nlm.nih.gov/pubmed/19254953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807653200
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