Single Chain Variable Fragment against Nicastrin Inhibits the γ-Secretase Activity

γ-Secretase is a membrane protein complex that catalyzes intramembrane proteolysis of a variety of substrates including the amyloid β precursor protein of Alzheimer disease. Nicastrin (NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of t...

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Detalhes bibliográficos
Main Authors: Hayashi, Ikuo, Takatori, Sho, Urano, Yasuomi, Iwanari, Hiroko, Isoo, Noriko, Osawa, Satoko, Fukuda, Maiko A., Kodama, Tatsuhiko, Hamakubo, Takao, Li, Tong, Wong, Philip C., Tomita, Taisuke, Iwatsubo, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788834/
https://ncbi.nlm.nih.gov/pubmed/19684016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055061
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