Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin

Several lines of evidence suggest that aberrant Notch signaling contributes to the development of several types of cancer. Activation of Notch receptor is executed through intramembrane proteolysis by γ-secretase, which is a multimeric membrane-embedded protease comprised of presenilin, nicastrin (N...

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Detalhes bibliográficos
Main Authors: Hayashi, I, Takatori, S, Urano, Y, Miyake, Y, Takagi, J, Sakata-Yanagimoto, M, Iwanari, H, Osawa, S, Morohashi, Y, Li, T, Wong, PC, Chiba, S, Kodama, T, Hamakubo, T, Tomita, T, Iwatsubo, T
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058788/
https://ncbi.nlm.nih.gov/pubmed/21725355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.265
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