Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons

Mutations in the presenilin genes (PS1, PS2) have been linked to the majority of familial Alzheimer’s disease (AD). Although great efforts have been made to investigate pathogenic PS mutations, which ultimately cause an increase in the toxic form of β-amyloid (Aβ), the intrinsic physiological functi...

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Bibliografische gegevens
Gepubliceerd in:eNeuro
Hoofdauteurs: Watanabe, Hirotaka, Imaizumi, Kent, Cai, Tetsuo, Zhou, Zhi, Tomita, Taisuke, Okano, Hideyuki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2021
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Research Article: New Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932187/
https://ncbi.nlm.nih.gov/pubmed/33608391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0500-20.2021
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