Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase

γ-Secretase is an intramembrane-cleaving protease that generates the toxic species of the amyloid-β peptide (Aβ) that is responsible for the pathology of Alzheimer disease. The catalytic subunit of γ-secretase is presenilin 1 (PS1), which is a polytopic membrane protein with a hydrophilic catalytic...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Cai, Tetsuo, Morishima, Kanan, Takagi-Niidome, Shizuka, Tominaga, Aya, Tomita, Taisuke
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6807281/
https://ncbi.nlm.nih.gov/pubmed/31527118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0838-19.2019
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