Functional Analysis of the Transmembrane Domains of Presenilin 1: PARTICIPATION OF TRANSMEMBRANE DOMAINS 2 AND 6 IN THE FORMATION OF INITIAL SUBSTRATE-BINDING SITE OF γ-SECRETASE

γ-Secretase is a multimeric membrane protein complex composed of presenilin (PS), nicastrin, Aph-1, and Pen-2, which mediates intramembrane proteolysis of a range of type I transmembrane proteins. We previously analyzed the functional roles of the N-terminal transmembrane domains (TMDs) 1–6 of PS1 i...

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Autors principals: Watanabe(渡邊, Naoto, 直登), Takagi(高木, Shizuka, 穏香), Tominaga(富永, Aya, 綾), Tomita(富田, Taisuke, 泰輔), Iwatsubo(岩坪, Takeshi, 威)
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Membrane Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888384/
https://ncbi.nlm.nih.gov/pubmed/20418378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.101287
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