טוען...
Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production
γ-Secretase is an intramembrane-cleaving protease that produces amyloid-β peptide 42 (Aβ(42)), which is the toxic and aggregation-prone species of Aβ that causes Alzheimer's disease. Here, we used the substituted cysteine accessibility method to analyze the structure of transmembrane domains (T...
שמור ב:
| הוצא לאור ב: | J Neurosci |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Society for Neuroscience
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6604815/ https://ncbi.nlm.nih.gov/pubmed/26818522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5090-14.2016 |
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