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Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production
γ-Secretase is an intramembrane-cleaving protease that produces amyloid-β peptide 42 (Aβ(42)), which is the toxic and aggregation-prone species of Aβ that causes Alzheimer's disease. Here, we used the substituted cysteine accessibility method to analyze the structure of transmembrane domains (T...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6604815/ https://ncbi.nlm.nih.gov/pubmed/26818522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5090-14.2016 |
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