Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production

γ-Secretase is an intramembrane-cleaving protease that produces amyloid-β peptide 42 (Aβ(42)), which is the toxic and aggregation-prone species of Aβ that causes Alzheimer's disease. Here, we used the substituted cysteine accessibility method to analyze the structure of transmembrane domains (T...

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Vydáno v:J Neurosci
Hlavní autoři: Tominaga, Aya, Cai, Tetsuo, Takagi-Niidome, Shizuka, Iwatsubo, Takeshi, Tomita, Taisuke
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604815/
https://ncbi.nlm.nih.gov/pubmed/26818522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5090-14.2016
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