Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

BACKGROUND: Amyloid-β peptide ending at 42nd residue (Aβ42) is believed as a pathogenic peptide for Alzheimer disease. Although γ-secretase is a responsible protease to generate Aβ through a processive cleavage, the proteolytic mechanism of γ-secretase at molecular level is poorly understood. RESULT...

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Hlavní autoři: Ohki, Yu, Shimada, Naoaki, Tominaga, Aya, Osawa, Satoko, Higo, Takuya, Yokoshima, Satoshi, Fukuyama, Tohru, Tomita, Taisuke, Iwatsubo, Takeshi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896738/
https://ncbi.nlm.nih.gov/pubmed/24410857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-7
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