Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

BACKGROUND: Amyloid-β peptide ending at 42nd residue (Aβ42) is believed as a pathogenic peptide for Alzheimer disease. Although γ-secretase is a responsible protease to generate Aβ through a processive cleavage, the proteolytic mechanism of γ-secretase at molecular level is poorly understood. RESULT...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Ohki, Yu, Shimada, Naoaki, Tominaga, Aya, Osawa, Satoko, Higo, Takuya, Yokoshima, Satoshi, Fukuyama, Tohru, Tomita, Taisuke, Iwatsubo, Takeshi
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896738/
https://ncbi.nlm.nih.gov/pubmed/24410857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-7
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍