Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

Amyloid-β peptide ending at the 42nd residue (Aβ42) is implicated in the pathogenesis of Alzheimer's disease (AD). Small compounds that exhibit selective lowering effects on Aβ42 production are termed γ-secretase modulators (GSMs) and are deemed as promising therapeutic agents against AD, altho...

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Detalhes bibliográficos
Main Authors: Ohki, Yu, Higo, Takuya, Uemura, Kengo, Shimada, Naoaki, Osawa, Satoko, Berezovska, Oksana, Yokoshima, Satoshi, Fukuyama, Tohru, Tomita, Taisuke, Iwatsubo, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243616/
https://ncbi.nlm.nih.gov/pubmed/22002539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.372
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