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Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1
Amyloid-β peptide ending at the 42nd residue (Aβ42) is implicated in the pathogenesis of Alzheimer's disease (AD). Small compounds that exhibit selective lowering effects on Aβ42 production are termed γ-secretase modulators (GSMs) and are deemed as promising therapeutic agents against AD, altho...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243616/ https://ncbi.nlm.nih.gov/pubmed/22002539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.372 |
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