An atomic structure of human γ-secretase

Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer’s disease (AD), with most AD-derived mutations mapping to the catalytic subunit presenilin 1 (PS1). Here we report an atomic structure of human γ-secretase at 3.4 Å resolution, determined by single-particle cryo-elec...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Bai, Xiao-chen, Yan, Chuangye, Yang, Guanghui, Lu, Peilong, Ma, Dan, Sun, Linfeng, Zhou, Rui, Scheres, Sjors H.W., Shi, Yigong
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568306/
https://ncbi.nlm.nih.gov/pubmed/26280335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14892
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